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Special SensesInfrequent were accommodation abnormality and dry eyeAlso observed were deafnessdiplopiaincreased intraocular pressureand mydriasis.
The therapeutic effect of bupropion is presumed to bein partdue to the antidepressant activity of 3 metaboliteshydroxybupropionthreohydrobupropionand erythrohydrobupropion3 Using cells expressing human transporters for DANEand serotoninit has been shown in vitro that bupropiontogether with the active metabolitesinhibits both the NE and DA human transportersdata on fileGlaxoSmithKlineResearch Triangle ParkN.CInhibition of serotonin reuptake was negligible even at the highest concentrations tested.
In addition to the adverse events noted abovethe following events have been reported in clinical trials and postmarketing experience with the sustained-release formulation of bupropion in depressed patients and in nondepressed smokersas well as in clinical trials and postmarketing clinical experience with the immediate-release formulation of bupropion.
Hemic and LymphaticInfrequent was ecchymosisAlso observed were anemialeukocytosisleukopenialymphadenopathypancytopeniaand thrombocytopeniaAltered PT and/or INRinfrequently associated with hemorrhagic or thrombotic complicationswere observed when bupropion was coadministered with warfarin.
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